Article
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
Journal of bacteriology - 1 Oct 1996
San José C, Monge R A, Pérez-Díaz R, Pla J, Nombela C
Abstract excerpt
The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.
Topics
- Adaptation, Physiological
- Calcium-Calmodulin-Dependent Protein Kinases
- Candida albicans
- Cloning, Molecular
- Genes, Fungal
- Genetic Complementation Test
- Glycerol
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutagenesis, Insertional
- Osmotic Pressure
- Phenotype
- Saccharomyces cerevisiae Proteins