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Article

The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans.

Microbiology (Reading, England) - 1 Feb 2009

Alonso-Monge Rebeca, Carvaihlo Sara, Nombela Cesar, Rial Eduardo, Pla Jesús

Abstract excerpt

Signal transduction pathways mediated by mitogen-activated protein kinases (MAPKs) play crucial roles in eukaryotic cells. In the pathogenic fungus Candida albicans the HOG MAPK pathway regulates the response to external stresses (osmotic and oxidative among others) and is involved in morphogenesis and virulence. We show here that the lack of the Hog1 MAPK increases the sensitivity of this fungus to inhibitors of...

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PMID: 19202089
DOI: 10.1099/mic.0.023309-0

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