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Article

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

The Journal of biological chemistry - 30 Mar 2012

Shilling Dustin, Mak Don-On Daniel, Kang David E, Foskett J Kevin

Abstract excerpt

Familial Alzheimer disease (FAD) is linked to mutations in the presenilin (PS) homologs. FAD mutant PS expression has several cellular consequences, including exaggerated intracellular Ca(2+) ([Ca(2+)](i)) signaling due to enhanced agonist sensitivity and increased magnitude of [Ca(2+)](i) signals. The mechanisms underlying these phenomena remain controversial. It has been proposed that PSs are constitutively...

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Identifiers

PMID: 22311977
DOI: 10.1074/jbc.M111.300491
PMCID: PMC3322867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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