Article
LINC01149 variant modulates MICA expression that facilitates hepatitis B virus spontaneous recovery but increases hepatocellular carcinoma risk.
Oncogene - 1 Feb 2020
Zhong Rong, Tian Jianbo, Fu Mingpeng, Ma Simin, Liu Li, Li Jiaoyuan, Shen Na, Ke Juntao, Yang Yang, Gong Yajie, Zhu Ying, Wang Ying, Gong Jing, Chang Jiang, Lei Ping, Cheng Xiang, Huang Kun, Shen Guanxin, Miao Xiaoping
Abstract excerpt
Interpreting disease-causing variants, especially in noncoding regions by genome-wide association studies (GWAS), has become one of the most challenging and demanding tasks. We hypothesized that functional lncRNAs variants in GWAS-identified loci might alter expression level of genes associated with persistent HBV infection and hepatocellular carcinoma (HCC). Integrated bioinformatics approaches were used to...
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