A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma.

doi:10.1371/journal.pone.0032230

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Article

A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma.

PloS one - 1 Jan 2012

Liu Yao, Zhang Yixin, Wen Juan, Liu Li, Zhai Xiangjun, Liu Jibin, Pan Shandong, Chen Jianguo, Shen Hongbing, Hu Zhibin

Abstract excerpt

BACKGROUND: MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles in diverse processes including immune response and tumorigenesis. A single nucleotide polymorphism (SNP), rs999885, is located in the promoter region of MCM7. METHODS: We performed a case-control study including 1300 HBV-positive hepatocellular carcinoma (HCC) cases, 1344 HBV persistent carriers and 1344 subjects with HBV...

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PMID: 22393390
DOI: 10.1371/journal.pone.0032230
PMCID: PMC3290543

Genes

MCM7

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