Article
High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray.
Molecular cancer research : MCR - 1 May 2009
Yin Dong, Ogawa Seishi, Kawamata Norihiko, Tunici Patrizia, Finocchiaro Gaetano, Eoli Marica, Ruckert Christian, Huynh Thien, Liu Gentao, Kato Motohiro, Sanada Masashi, Jauch Anna, Dugas Martin, Black Keith L, Koeffler H Phillip
Abstract excerpt
Glioblastoma multiforme (GBM) is an extremely malignant brain tumor. To identify new genomic alterations in GBM, genomic DNA of tumor tissue/explants from 55 individuals and 6 GBM cell lines were examined using single nucleotide polymorphism DNA microarray (SNP-Chip). Further gene expression analysis relied on an additional 56 GBM samples. SNP-Chip results were validated using several techniques, including...
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