Article

Cardiac electrical abnormalities in a mouse model of left ventricular non-compaction cardiomyopathy

2024-11-22

Abstract excerpt

Mutations in MINDBOMB 1 ( MIB1 ), encoding an E3 ubiquitin ligase of the NOTCH signaling pathway, cause left ventricular noncompaction cardiomyopathy (LVNC) in mice and humans, increasing the risk of arrhythmia and left ventricular dysfunction. This study aimed to investigate the effect of MIB1 mutations on cardiac electrical activity. We examined male Mib1 flox ;Tnnt2 Cre mice, a disease model of LVNC, and...

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Literature Corpus work: c09f103e-b634-5de4-a9de-975293f04ce2
DOI: 10.1101/2024.11.20.624427

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