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Article

Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes.

Cells - 29 Sept 2022

Stevens Tyler L, Manring Heather R, Wallace Michael J, Argall Aaron, Dew Trevor, Papaioannou Peter, Antwi-Boasiako Steve, Xu Xianyao, Campbell Stuart G, Akar Fadi G, Borzok Maegen A, Hund Thomas J, Mohler Peter J, Koenig Sara N, El Refaey Mona

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete penetrance is a common feature in ACM families, complicating the understanding of how external stressors contribute towards disease development. To analyze the dual...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36231013
DOI: 10.3390/cells11193049
PMCID: PMC9562631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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