Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy.

Cardiovascular research - 15 Aug 2005

Gard Joseph J, Yamada Kiyomi, Green Karen G, Eloff Benjamin C, Rosenbaum David S, Wang Xuejun, Robbins Jeffrey, Schuessler Richard B, Yamada Kathryn A, Saffitz Jeffrey E

Abstract excerpt

OBJECTIVE: We studied a transgenic mouse model of human desmin-related cardiomyopathy with cardiac-specific expression of a 7-amino acid deletion mutation in desmin (D7-des) to test the hypothesis that impaired linkage between desmin and desmosomes alters expression and function of the electrical coupling protein, connexin43 (Cx43). METHODS: Expression of Cx43 and selected mechanical junctions proteins was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathies
Share to Desmin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Gap Junctions

Share to Microscopy, Confocal

Share to Models, Animal

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Source

Identifiers

PMID: 15913582
DOI: 10.1016/j.cardiores.2005.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy.PMID 15913582Read ↗

Desmosomal junctions are necessary for adult sinus node function.Semantic proximity Read ↗

The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease.Semantic proximity Read ↗

Mouse model of desmin-related cardiomyopathy.Semantic proximity Read ↗

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.Semantic proximity Read ↗

Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse modelSemantic proximity Read ↗

Desmin p.R406W mutation is associated with arrhythmias through structural and electrophysiological remodelingSemantic proximity Read ↗

Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.Semantic proximity Read ↗

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodelingSemantic proximity Read ↗

Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.Semantic proximity Read ↗

Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling.Semantic proximity Read ↗

Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.Semantic proximity Read ↗

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.