Article
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.
Journal of neuropathology and experimental neurology - 1 Jan 2020
Katsumata Yuriko, Fardo David W, Bachstetter Adam D, Artiushin Sergey C, Wang Wang-Xia, Wei Angela, Brzezinski Lena J, Nelson Bela G, Huang Qingwei, Abner Erin L, Anderson Sonya, Patel Indumati, Shaw Benjamin C, Price Douglas A, Niedowicz Dana M, Wilcock Donna W, Jicha Gregory A, Neltner Janna H, Van Eldik Linda J, Estus Steven, Nelson Peter T
Abstract excerpt
We found evidence of late-onset Alzheimer disease (LOAD)-associated genetic polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another gene: Adaptor Related Protein Complex 2 Subunit Alpha 2 (AP2A2). PCR analyses on genomic DNA samples confirmed that the size of the MUC6 variable number tandem repeat (VNTR) region was highly polymorphic. In a cohort of autopsied subjects with...
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