Article

Autoimmunity to hypocretin and molecular mimicry to flu antigens in Type 1 narcolepsy

2018-07-26

Abstract excerpt

Type 1 narcolepsy (T1N) is caused by hypocretin (HCRT) neuronal loss. Association with the Human Leukocyte Antigen (HLA)-DQB1*06:02/DQA1*01:02 (98% vs 25%) heterodimer (DQ0602), T cell receptor (TCR) and other immune loci suggest autoimmunity but autoantigen(s) are unknown. Onset is seasonal and associated with influenza A, notably pandemic 2009 H1N1 (pH1N1). An extensive unbiased DQ0602 binding peptide screen was...

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Literature Corpus work: 65675c08-bd9f-5746-a729-66e933a1eceb
DOI: 10.1101/378109

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