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Article

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.

Science translational medicine - 20 Nov 2019

Mensah Kofi A, Chen Jeff W, Schickel Jean-Nicolas, Isnardi Isabelle, Yamakawa Natsuko, Vega-Loza Andrea, Anolik Jennifer H, Gatti Richard A, Gelfand Erwin W, Montgomery Ruth R, Horowitz Mark C, Craft Joe E, Meffre Eric

Abstract excerpt

Patients with rheumatoid arthritis (RA) may display atypical CD21-/lo B cells in their blood, but the implication of this observation remains unclear. We report here that the group of patients with RA and elevated frequencies of CD21-/lo B cells shows decreased ataxia telangiectasia-mutated (ATM) expression and activation in B cells compared with other patients with RA and healthy donor controls. In agreement...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31748230
DOI: 10.1126/scitranslmed.aaw4626
PMCID: PMC7167286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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