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Article

Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis.

Journal of autoimmunity - 1 Jan 2017

Hu Fanlei, Liu Hongjiang, Liu Xu, Zhang Xia, Xu Liling, Zhu Huaqun, Li Yingni, Shi Lianjie, Ren Limin, Zhang Jian, Li Zhanguo, Jia Yuan

Abstract excerpt

Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus impairing their immunosuppressive functions in RA and exacerbating the disease progression. Our...

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Identifiers

PMID: 27640100
DOI: 10.1016/j.jaut.2016.09.002

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TNF

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