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Article

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

18 May 2009

Abstract excerpt

In rheumatoid arthritis (RA), dysfunctional T cells sustain chronic inflammatory immune responses in the synovium. Even unprimed T cells are under excessive replication pressure, suggesting an intrinsic defect in T cell regeneration. In naive CD4 CD45RA(+) T cells from RA patients, DNA damage load and apoptosis rates were markedly higher than in controls; repair of radiation-induced DNA breaks was blunted and...

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PMID: 19451263
DOI: 10.1084/jem.20082251

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