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Article

A Hardy-Weinberg equilibrium test for analyzing population genetic surveys with complex sample designs.

American journal of epidemiology - 15 Apr 2010

Moonesinghe Ramal, Yesupriya Ajay, Chang Man-Huei, Dowling Nicole F, Khoury Muin J, Scott Alastair J

Abstract excerpt

Testing for deviations from Hardy-Weinberg equilibrium is a widely recommended practice for population-based genetic association studies. However, current methods for this test assume a simple random sample and may not be appropriate for sample surveys with complex survey designs. In this paper, the authors present a test for Hardy-Weinberg equilibrium that adjusts for the sample weights and correlation of data...

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PMID: 20237153
DOI: 10.1093/aje/kwq002

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