Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse.

Investigative ophthalmology & visual science - 1 Mar 2004

Alizadeh Azita, Clark John, Seeberger Teri, Hess John, Blankenship Tom, FitzGerald Paul G

Abstract excerpt

PURPOSE: The 129 strain of mouse carries a mutation in the gene for CP49 (phakinin), an intermediate filament protein thus far demonstrated only in the lens fiber cell. As such, these mice represent naturally occurring mutants of interest in the study of the lens cytoskeleton. However, this strain of mouse is also widely used as a source of embryonic stem cells in gene-targeting studies. The presence of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cattle

Share to Eye Proteins

Share to gamma-Crystallins

Share to Intermediate Filament Proteins

Share to Lens, Crystalline

Share to Mice, Inbred C57BL

Source

Identifiers

PMID: 14985306
DOI: 10.1167/iovs.03-0677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse.PMID 14985306Read ↗

Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens.Semantic proximity Read ↗

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton.Semantic proximity Read ↗

Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.Semantic proximity Read ↗

AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.Semantic proximity Read ↗

The predicted structure of chick lens CP49 and a variant thereof, CP49ins, the first vertebrate cytoplasmic intermediate filament protein with a lamin-like insertion in helix 1B.Semantic proximity Read ↗

Further analysis of the lens of ephrin-A5-/- mice: development of postnatal defects.Semantic proximity Read ↗

Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice.Semantic proximity Read ↗

Generation of an EphA4 conditional allele in mice.Semantic proximity Read ↗

The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak syndrome.Semantic proximity Read ↗

A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo rats.Semantic proximity Read ↗

Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts.Semantic proximity Read ↗

Molecular characterisation of the Hyp deletion and an improved assay for its detection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.