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Article

Site-specific acylation of a bacterial virulence regulator attenuates infection.

Nature chemical biology - 1 Jan 2020

Zhang Zhenrun J, Pedicord Virginia A, Peng Tao, Hang Howard C

Abstract excerpt

Microbiota generates millimolar concentrations of short-chain fatty acids (SCFAs) that can modulate host metabolism, immunity and susceptibility to infection. Butyrate in particular can function as a carbon source and anti-inflammatory metabolite, but the mechanism by which it inhibits pathogen virulence has been elusive. Using chemical proteomics, we found that several virulence factors encoded by Salmonella...

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Identifiers

PMID: 31740807
DOI: 10.1038/s41589-019-0392-5
PMCID: PMC8439376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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