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Article

Evaluation of pharmacochaperone-mediated rescue of mutant V2 receptor proteins.

European journal of pharmacology - 15 Dec 2019

Erdem Tuncdemir Beril, Mergen Hatice, Saglar Ozer Emel

Abstract excerpt

Nephrogenic Diabetes Insipidus is a rare disorder which is characterized by severe water imbalance in the body. The disease can be acquired or inherited. AVPR2 (arginine vasopressin type 2 receptor) mutations are responsible for genetical type of the disorder. Mutations in the AVPR2 gene may cause loss-of-function due to conformational defects. According to the mutation type, the three-dimensional structure of...

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PMID: 31738937
DOI: 10.1016/j.ejphar.2019.172803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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