Article

The rescue potentials of OPC-41061, OPC-31260 and OPC-21268 on mutant AVPR2s that cause nephrogenic diabetes insipidus

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>Purpose Nephrogenic Diabetes insipidus (NDI) is a rare disease which is characterized by polyuria and polydipsia. AVPR2 mutations can cause NDI. Mutants may not function properly since the mutations can affect their folding process and make them be trapped in the Endoplasmic reticulum (ER). Recent studies showed that pharmacological chaperones (PCs) may rescue mutant AVPR2s and they ca...

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Literature Corpus work: 1ed942a9-dcf8-5d9a-95f0-0703c1e15a07
DOI: 10.21203/rs.3.rs-3146169/v1

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