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Article

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations.

Biochimica et biophysica acta - 1 Jan 2015

Lim Liangzhong, Lee Xiaowen, Song Jianxing

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) cause familial amyotrophic lateral sclerosis (FALS), while wild-type SOD1 has been implicated in sporadic ALS (SALS). SOD1 mutants are now recognized to acquire one or more toxicities that include their association with mitochondrial and endoplasmic reticulum membranes but the underlying structural mechanism remains unknown. Here we determine NMR conformations of both...

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Identifiers

PMID: 25306968
DOI: 10.1016/j.bbamem.2014.10.002

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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