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Article

Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis.

The Journal of biological chemistry - 2 Oct 2009

Tiwari Ashutosh, Liba Amir, Sohn Se Hui, Seetharaman Sai V, Bilsel Osman, Matthews C Robert, Hart P John, Valentine Joan Selverstone, Hayward Lawrence J

Abstract excerpt

The mechanisms by which mutant variants of Cu/Zn-superoxide dismutase (SOD1) cause familial amyotrophic lateral sclerosis are not clearly understood. Evidence to date suggests that altered conformations of amyotrophic lateral sclerosis mutant SOD1s trigger perturbations of cellular homeostasis that ultimately cause motor neuron degeneration. In this study we correlated the metal contents and disulfide bond status...

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Identifiers

PMID: 19651777
DOI: 10.1074/jbc.M109.043729
PMCID: PMC2785702

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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