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Article

Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure.

Cardiovascular drugs and therapy - 1 Dec 2019

Luzum Jasmine A, Ting Christopher, Peterson Edward L, Gui Hongsheng, Shugg Tyler, Williams L Keoki, Li Liang, Sadee Wolfgang, Wang Danxin, Lanfear David E

Abstract excerpt

PURPOSE: Protein kinase C alpha (gene: PRKCA) is a key regulator of cardiac contractility. Two genetic variants have recently been discovered to regulate PRKCA expression in failing human heart tissue (rs9909004 [T → C] and rs9303504 [C → G]). The association of those variants with clinical outcomes in patients with heart failure (HF), and their interaction with HF drug efficacy, is unknown. METHODS: Patients...

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Source

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Identifiers

PMID: 31728800
DOI: 10.1007/s10557-019-06909-6
PMCID: PMC7197488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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