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Article

Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes.

Pharmacogenomics - 1 Oct 2008

Cresci Sharon, Jones Philip G, Sucharov Carmen C, Marsh Sharon, Lanfear David E, Garsa Adam, Courtois Michael, Weinheimer Carla J, Wu Jun, Province Michael A, Kelly Daniel P, McLeod Howard L, Spertus John A

Abstract excerpt

AIMS: beta-blockers (BB) are strongly recommended after an acute coronary syndrome (ACS), although all patients may not benefit. Causes for variable patient responses to BB are unknown. Given that myocardial ischemia and BB influence metabolic processes regulated by peroxisome proliferator-activated receptor alpha (PPARalpha), we hypothesized that interactions between polymorphisms of the PPARalpha gene (PPARA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18855529
DOI: 10.2217/14622416.9.10.1403
PMCID: PMC2586954

Genes

PPARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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