Article
β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant.
Pharmacogenomics - 1 Sept 2010
Dörr Marcus, Schmidt Carsten O, Spielhagen Thomas, Bornhorst Alexa, Hentschel Katharina, Franz Christina, Empen Klaus, Kocher Thomas, Diehl Scott R, Kroemer Heyo K, Völzke Henry, Ewert Ralf, Felix Stephan B, Rosskopf Dieter
Abstract excerpt
AIM: Impaired heart rate (HR) response to exercise is associated with increased cardiovascular morbidity and mortality. We analyzed whether common variants (rs5443/C825T and rs5442/G814A) in the G-protein β3 subunit (GNB3) gene modulate interindividual variation in β-blocker responses with respect to HR. MATERIALS & METHODS: Among 1614 subjects (347 current β-blocker users) of a population-based study, HR during...
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