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Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

14 Nov 2019

Abstract excerpt

Accumulation of DNA damage and myeloid-skewed differentiation characterize aging of the hematopoietic system, yet underlying mechanisms remain incompletely understood. Here, we show that aging hematopoietic progenitor cells particularly of the myeloid branch exhibit enhanced resistance to bulky DNA lesions-a relevant type of DNA damage induced by toxins such as cancer drugs or endogenous aldehydes. We identified...

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PMID: 31728056
DOI: 10.1038/s41375-019-0641-3

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