Article
Post-secretional activation of Protease IV by quorum sensing in Pseudomonas aeruginosa.
Scientific reports - 30 Jun 2017
Oh Jungmin, Li Xi-Hui, Kim Soo-Kyong, Lee Joon-Hee
Abstract excerpt
Protease IV (PIV), a key virulence factor of Pseudomonas aeruginosa is a secreted lysyl-endopeptidase whose expression is induced by quorum sensing (QS). We found that PIV expressed in QS mutant has severe reduction of activity in culture supernatant (CS), even though it is overexpressed to high level. PIV purified from the QS mutant (M-PIV) had much lower activity than the PIV purified from wild type (P-PIV). We...
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