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Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population.

Drug metabolism and pharmacokinetics - 1 Feb 2020

Higuchi Issei, Kimura Yuki, Kobayashi Masaki, Narumi Katsuya, Furugen Ayako, Miyoshi Hideaki, Nakamura Akinobu, Yamada Takehiro, Atsumi Tatsuya, Iseki Ken

Abstract excerpt

The present study aimed to characterize the relationships between plasma lactate, plasma alanine, monocarboxylate transporter (MCT) polymorphisms, and indices of diabetes in patients with type 2 diabetes (T2D) in Japan. Eighty-three patients with T2D were prospectively enrolled. The gluconeogenesis and glycogenolysis are enhanced and uptake of glucose is decreased in the T2D liver. Since the liver plays an...

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Identifiers

PMID: 31727576
DOI: 10.1016/j.dmpk.2019.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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