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Article

Identification of gene-environment interactions with marginal penalization.

Genetic epidemiology - 1 Mar 2020

Zhang Sanguo, Xue Yuan, Zhang Qingzhao, Ma Chenjin, Wu Mengyun, Ma Shuangge

Abstract excerpt

Gene-environment (G-E) interaction analysis has been extensively conducted for complex diseases. In marginal analysis, the common practice is to conduct likelihood-based (and other "standard") estimation with each marginal model, and then select significant G-E interactions and main effects based on p values and multiple comparisons adjustment. One limitation of this approach is that the identification results...

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Identifiers

PMID: 31724772
DOI: 10.1002/gepi.22270
PMCID: PMC7028443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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