Article
[Familial Amyotrophic Lateral Sclerosis].
Brain and nerve = Shinkei kenkyu no shinpo - 1 Nov 2019
Suzuki Naoki, Nishiyama Ayumi, Kato Masaaki, Warita Hitoshi, Aoki Masashi
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most rapidly progressive motor neuron disease (MND) in adults, characterized by the selective death of motor neurons in the motor cortex, brainstem, and spinal cord. Riluzole and edaravone are the only approved drugs available in Japan to date. Approximately 10% of ALS cases are familial in rature, defined as the existence of disease-causing mutation. SOD1 is the most...
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