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Article

Advances in genetics research in the pathogenesis of amyotrophic lateral sclerosis.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 28 Dec 2020

Wang Yan, Yi Hang, Liao Qiao, Bi Fangfang

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease affecting the upper and lower motor neurons. It is characterized by progressive muscle weakness, atrophy and ultimate death due to dysphagia and dyspnea. There are many causes of ALS, among which the genetic factors show great relevance. Imbalance of protein homeostasis in neurons, prion-like proliferation and propagation of abnormal...

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Identifiers

PMID: 33473007
DOI: 10.11817/j.issn.1672-7347.2020.190506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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