Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci.

Abstract excerpt

Large genome-wide association studies (GWAS) have identified loci that are associated with complex traits and diseases, but index variants are often not causal and reside in non-coding regions of the genome. To gain a better understanding of the relevant biological mechanisms, intermediate traits such as gene expression and protein levels are increasingly being investigated because these are likely mediators...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression
• Share to Genetic Variation
• Share to Genome-Wide Association Study