Article
ROCK1 is associated with non-syndromic cleft palate.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Feb 2020
Palmieri Annalisa, Scapoli Luca, Carrozzo Marco, Cura Francesca, Morselli Paolo Giovanni, Pannuto Lucia, Nouri Nayereh, Carinci Francesco, Lauritano Dorina, Martinelli Marcella
Abstract excerpt
BACKGROUND: Craniofacial morphogenesis is the result of an intricate multistep network of tightly controlled spatial and temporal signalling that involves several molecules and transcription factors organized into highly coordinated pathways. Any alteration in even one step of this delicate process can lead to congenital malformations such as cleft palate. One of the first steps in embryonal orofacial development...
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