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Article

CaSR Activation Triggers Mandibular Overgrowth in Familial Mandibular Prognathism Patients and Mice.

Journal of dental research - 1 Jul 2026

Fang H, Li P, Wei Y, Li H, Wang P, Yang X, Yu H, Fan Y, Zhu S, Bi R

Abstract excerpt

Mandibular prognathism (MP) is the most common type of dentomaxillofacial deformity in East Asian populations. Genetic studies have revealed several MP-associated loci, suggesting that MP could be inherited as familial MP (fMP). However, functional verifications and in-depth mechanistic investigations of these loci are limited. For this study, we recruited 5 fMP families with 17 fMP members and 7 normal members....

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Source

Identifiers

PMID: 41185400
DOI: 10.1177/00220345251384290

Genes

CASR
GNAQ

Variants

rs117375173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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