Article
Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans.
Molecular genetics and metabolism - 1 Mar 2015
Oppelt Sarah A, Sennott Erin M, Tolan Dean R
Abstract excerpt
The rise in fructose consumption, and its correlation with symptoms of metabolic syndrome (MBS), has highlighted the need for a better understanding of fructose metabolism. To that end, valid rodent models reflecting the same metabolism as in humans, both biochemically and physiologically, are critical. A key to understanding any type of metabolism comes from study of disease states that affect such metabolism. A...
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