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Article

DNA sequence differences are determinants of meiotic recombination outcome.

Scientific reports - 11 Nov 2019

Brown Simon D, Mpaulo Samantha J, Asogwa Mimi N, Jézéquel Marie, Whitby Matthew C, Lorenz Alexander

Abstract excerpt

Meiotic recombination is essential for producing healthy gametes, and also generates genetic diversity. DNA double-strand break (DSB) formation is the initiating step of meiotic recombination, producing, among other outcomes, crossovers between homologous chromosomes (homologs), which provide physical links to guide accurate chromosome segregation. The parameters influencing DSB position and repair are thus...

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PMID: 31712578
DOI: 10.1038/s41598-019-52907-x
PMCID: PMC6848502

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