Article
Recent advances in MDS mutation landscape: Splicing and signalling.
Advances in biological regulation - 1 Jan 2020
Follo Matilde Y, Pellagatti Andrea, Ratti Stefano, Ramazzotti Giulia, Faenza Irene, Fiume Roberta, Mongiorgi Sara, Suh Pann-Ghill, McCubrey James A, Manzoli Lucia, Boultwood Jacqueline, Cocco Lucio
Abstract excerpt
Recurrent cytogenetic aberrations, genetic mutations and variable gene expression have been consistently recognized in solid cancers and in leukaemia, including in Myelodysplastic Syndromes (MDS). Besides conventional cytogenetics, the growing accessibility of new techniques has led to a deeper analysis of the molecular significance of genetic variations. Indeed, gene mutations affecting splicing genes, as well...
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