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Article

Sex-specific epigenetic alterations of the hypothalamic Agrp-Pomc system do not explain 'diabesity' in the offspring of high-fat diet (HFD) overfed maternal rats.

The Journal of nutritional biochemistry - 1 Jan 2020

Schellong Karen, Melchior Kerstin, Ziska Thomas, Henrich Wolfgang, Rancourt Rebecca C, Plagemann Andreas

Abstract excerpt

Maternal high-fat diet (HFD) overfeeding pre- and during pregnancy and lactation may 'program' a 'diabesity' predisposition in the offspring, for inconclusive reasons. Acquired alterations of the hypothalamic promoter methylation and mRNA expression of the satiety neurohormone Pomc are possibly of critical importance here. We investigated within one developmental approach, including male and female rats, the...

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Source

Identifiers

PMID: 31710935
DOI: 10.1016/j.jnutbio.2019.108257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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