Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.

Obesity (Silver Spring, Md.) - 1 Mar 2011

Carmody Jill S, Wan Phyllis, Accili Domenico, Zeltser Lori M, Leibel Rudolph L

Abstract excerpt

Maternal obesity can influence susceptibility to obesity and type 2 diabetes in progeny. We examined the relationship of maternal insulin resistance (IR), a metabolically important consequence of increased adiposity, to adverse consequences of obesity for fetal development. We used mice heterozygous for a null allele of the insulin receptor (Insr) to study the contributions of maternal IR to offspring phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Dietary Fats
Share to Hypothalamus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuropeptide Y

Share to Pregnancy Complications

Share to Pro-Opiomelanocortin

Share to Receptor, Insulin

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 20948526
DOI: 10.1038/oby.2010.245
PMCID: PMC3234171

Genes

NPY
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.PMID 20948526Read ↗

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.Semantic proximity Read ↗

Influence of abnormally high leptin levels during pregnancy on metabolic phenotypes in progeny mice.Semantic proximity Read ↗

Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gainSemantic proximity Read ↗

Sexual Dimorphism in Offspring Glucose-Sensitive Hypothalamic Gene Expression and Physiological Responses to Maternal High-Fat Diet FeedingSemantic proximity Read ↗

Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies.Semantic proximity Read ↗

Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunctionSemantic proximity Read ↗

Fish Oil Improves Offspring Metabolic Health of Paternal Obese Mice by Targeting Adipose TissueSemantic proximity Read ↗

The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype.Semantic proximity Read ↗

High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice.Semantic proximity Read ↗

Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.Semantic proximity Read ↗

Maternal Obesity-Induced Endoplasmic Reticulum Stress Causes Metabolic Alterations and Abnormal Hypothalamic Development in the OffspringSemantic proximity Read ↗

Emergence of insulin resistance in juvenile baboon offspring of mothers exposed to moderate maternal nutrient reduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.