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Article

Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding

1 Jan 2010

Abstract excerpt

AIM: Prenatal and neonatal overfeeding programs a permanent obesity and diabetes disposition, e.g., due to induction of hypothalamic insulin resistance. We investigated acquired alterations of the DNA methylation pattern of the hypothalamic insulin receptor promoter (IRP) which might be an underlying molecular mechanism. METHODS: Neonatal overfeeding was induced by rearing Wistar rats in small litters (SL)....

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Identifiers

PMID: 20443665
DOI: 10.1515/jpm.2010.051

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