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Magnetic concentration of allele-specific products from recombinase polymerase amplification.

Analytica chimica acta - 27 Dec 2019

Martorell Sara, Tortajada-Genaro Luis A, Maquieira Ángel

Abstract excerpt

The studied challenge is the specific detection of low-abundant genomic variants that differ by a single nucleotide from the wild type. The combination of blocked recombinase polymerase amplification (RPA) and selective capture by probes immobilised on magnetic-core particles integrated into a flow system is presented. The sensing principle was demonstrated as the effective concentration-detection of the specific...

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PMID: 31708032
DOI: 10.1016/j.aca.2019.10.006

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