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Article

Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner.

The Journal of nutritional biochemistry - 1 Jan 2020

Toscano Rocio, Millan-Linares Maria C, Lemus-Conejo Ana, Claro Carmen, Sanchez-Margalet Victor, Montserrat-de la Paz Sergio

Abstract excerpt

Inhibiting M1 microglia phenotype while stimulating the M2 microglia has been suggested as a potential therapeutic approach for the treatment of neuroinflammatory diseases. Our hypothesis is that the type of dietary fatty acids (FAs) into human postprandial triglyceride-rich lipoproteins (TRLs) could modulate the plasticity of microglia. We isolated TRLs at the postprandial hypertriglyceridemic peak from blood...

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PMID: 31707281
DOI: 10.1016/j.jnutbio.2019.108248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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