A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry.

doi:10.1016/j.vetimm.2019.109957

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Article

A new polymorphic epitope of bovine CD4 antigen evidenced by flow cytometry.

Veterinary immunology and immunopathology - 1 Jan 2020

Grandoni Francesco, Napolitano Francesco, Scatà Maria Carmela, De Matteis Giovanna

Abstract excerpt

Cluster of differentiation 4 (CD4) is the accessory protein non-covalently bounded to T cell receptor (TCR) that recognize an invariant region of MHC class II on antigen presenting cell (APC). Its cytoplasmic tail, physically associated with a protein tyrosine kinase, is important in the activation of helper/inducer T (TH) lymphocytes. The anti-bovine CD4 monoclonal antibody (mAb) CC8 is a clone usefully used in...

Topics

Animals
Breeding
CD4 Antigens
Cattle
Cells, Cultured
Epitopes
Female
Flow Cytometry
Mutation, Missense
Phenotype
Polymorphism, Genetic
Protein Binding
Receptors, Antigen, T-Cell
Th1 Cells

Source

Open in PubMed

Identifiers

PMID: 31706083
DOI: 10.1016/j.vetimm.2019.109957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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