APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy.

doi:10.1016/j.biopha.2019.109572

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APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2020

Siraj Abdul K, Kumar Parvathareddy Sandeep, Pratheeshkumar Poyil, Padmaja Divya Sasidharan, Ahmed Saeeda Omer, Melosantos Roxanne, Begum Rafia, Concepcion Rica Micaela J A, Al-Sanea Nasser, Ashari Luai H, Abduljabbar Alaa, Al-Dayel Fouad, Al-Kuraya Khawla S

Abstract excerpt

Colorectal Cancer (CRC) is highly heterogeneous for which prognosis is dependent mainly on clinical staging. There is a need to stratify subpopulations of CRC on molecular basis to better predict outcome and therapy response. Truncating mutations in adenomatous polyposis coli (APC) are well-described events in CRC carcinogenesis. Clinical and genotypic characterization of Middle Eastern CRC based on presence and...

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PMID: 31704613
DOI: 10.1016/j.biopha.2019.109572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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