Article
An integration-free iPSC line, ICCSICi007-A, derived from a female Alzheimer's disease patient with the APOE-ε4/ε4 alleles.
Stem cell research - 1 Dec 2019
Díaz-Guerra Eva, Rodríguez-Traver Eva, Moreno-Jiménez Elena P, de Rojas Itziar, Rodríguez César, Orera María, Hernández Isabel, Ruiz Agustín, Vicario Carlos
Abstract excerpt
The epsilon4 (ε4) allele of the APOE gene, which encodes the apolipoprotein E4 (ApoE4), is the strongest genetic risk factor known for late-onset Alzheimer´s disease (LOAD). Here, we present the characterization of an iPSC line generated from dermal fibroblasts of a female AD patient using Sendai viral vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The iPSCs maintained the original...
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