The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma.

doi:10.1158/1078-0432.CCR-19-0556

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Article

The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2020

Zhuo Minglei, Guan Yanfang, Yang Xue, Hong Lingzhi, Wang Yuqi, Li Zhongwu, Chen Runzhe, Abbas Hussein A, Chang Lianpeng, Gong Yuhua, Wu Nan, Zhong Jia, Chen Wenting, Chen Hanxiao, Dong Zhi, Zhu Xiang, Li Jianjie, Wang Yuyan, An Tongtong, Wu Meina, Wang Ziping, Wang Jiayin, Roarty Emily B, Rinsurongkawong Waree, Lewis Jeff, Roth Jack A, Swisher Stephen G, Lee J Jack, Heymach John V, Wistuba Ignacio I, Kalhor Neda, Yang Ling, Yi Xin, Futreal P Andrew, Glisson Bonnie S, Xia Xuefeng, Zhang Jianjun, Zhao Jun

Abstract excerpt

PURPOSE: The optimal systemic treatment for pulmonary large-cell neuroendocrine carcinoma (LCNEC) is still under debate. Previous studies showed that LCNEC with different genomic characteristics might respond differently to different chemotherapy regimens. In this study, we sought to investigate genomic subtyping using cell-free DNA (cfDNA) analysis in advanced LCNEC and assess its potential prognostic and...

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PMID: 31694833
DOI: 10.1158/1078-0432.CCR-19-0556
PMCID: PMC7024651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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