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Article

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits.

Genome biology - 6 Nov 2019

Jiang Lin, Xue Chao, Dai Sheng, Chen Shangzhen, Chen Peikai, Sham Pak Chung, Wang Haijun, Li Miaoxin

Abstract excerpt

The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association studies (GWASs). This framework consists of three components which run iteratively to produce a converged prioritization list of driver...

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Identifiers

PMID: 31694669
DOI: 10.1186/s13059-019-1801-5
PMCID: PMC6836538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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