Article

Estimating driver-tissues by robust selective expression of genes associated with complex diseases or traits

2018-12-17

Abstract excerpt

The driver tissues or cell-types of many human diseases, in which susceptibility genes cause the diseases, remain elusive. We developed a framework to detect the causal-tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association study (GWAS). The core method of the framework is a new robust z-score to estimate genes’ expression selectivity. Through...

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Literature Corpus work: 8b38c45c-2b3b-5e63-aaff-848ba05057f6
DOI: 10.1101/491878

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