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Article

Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.

PLoS computational biology - 1 Jan 2013

Mariani Simona, Dell'Orco Daniele, Felline Angelo, Raimondi Francesco, Fanelli Francesca

Abstract excerpt

A number of incurable retinal diseases causing vision impairments derive from alterations in visual phototransduction. Unraveling the structural determinants of even monogenic retinal diseases would require network-centered approaches combined with atomistic simulations. The transducin G38D mutant associated with the Nougaret Congenital Night Blindness (NCNB) was thoroughly investigated by both mathematical...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 6
Share to Eye Diseases, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits

Share to Guanosine Triphosphate

Share to Night Blindness

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Share to Vision, Ocular

Source

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Identifiers

PMID: 24009494
DOI: 10.1371/journal.pcbi.1003207
PMCID: PMC3757061

Genes

RGS9

Provenance

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