Article

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA viruses

2021-06-28

Abstract excerpt

Debilitating mutation in RNA viruses can be repaired via different mechanisms, while triggering factors of mutation repair were poorly understood. In this study, multiple levels of triggering factors of mutation repair was identified based on genetic damage of tRNA-like structure (TLS) in cucumber mosaic virus (CMV). TLS mutation in different RNAs of CMV distinctively impacted the pathogenicity and mutation repair...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbdf4b2b-2d06-5ac6-98ef-72a1a9752f70
DOI: 10.1101/2021.06.28.450159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA virusesDOI 10.1101/2021.06.28.450159Read

Emergency Services of Viral RNAs: Repair and Remodeling.Semantic proximity Read

Structural transition of replicable RNAs during in vitro evolution with Qβ replicase.Semantic proximity Read

Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution.Semantic proximity Read

Virus mutators and antimutators: roles in evolution, pathogenesis and emergence.Semantic proximity Read

Mutational robustness and resilience of a replicative cis-element of RNA virus: Promiscuity, limitations, relevance.Semantic proximity Read

The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate.Semantic proximity Read

Quasispecies and the development of new antiviral strategies.Semantic proximity Read

Replication mode and landscape topology differentially affect RNA virus mutational load and robustness.Semantic proximity Read

Energy dynamics for systemic configurations of virus-host co-evolutionSemantic proximity Read

Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet.Semantic proximity Read

Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.Semantic proximity Read

Mathematical model of replication–mutation dynamics in coronavirusesSemantic proximity Read