Article
Persistent Fibrosis in Heart Failure With a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations.
Journal of the American Heart Association - 15 Apr 2025
Biggs Rachel M, Zhang Yuhua, Silverman Daniel N, Baicu Catalin F, Van Laer An O, Wakefield Lauren, Bhatt Devki, Masline Stephanie, Neff Lily S, Kilic Arman, Witer Lucas J, Houston Brian A, Coeyman Samuel J, Richardson William J, Zile Michael R, Bradshaw Amy D
Abstract excerpt
BACKGROUND: Myocardial fibrosis is prevalent in cardiomyopathies that result in heart failure with reduced ejection fraction. Heart failure with reduced ejection fraction treated with a left ventricular assist device (LVAD) yields hemodynamic unloading and may provide partial cardiomyocyte recovery, but contemporary studies reveal no consistent reductions in fibrosis. This study tested the hypothesis that,...
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